• M.D., Doctor of Medicine (Università Cattolica, Facoltà di Medicina e Chirurgia, Roma, Italy, 1984; summa cum laude)
• Specialty in Emergency Surgery (Università Statale, Milano, Italy, 1989; 70/70 score)
• M.Sc., Master in Applied Mathematics (UMBC, University of Maryland at Baltimore County, Baltimore, USA, 1991; core curricula in Analysis and Algebra)
• Ph.D. in Applied Mathematics (Universite' de Pau et des Pays de l'Adour, Pau, France, 1995; Dynamical Systems, Mention Tres Honorable et Félicitations, full score summa cum laude)
• J.D., Juris Doctor (Laurea Magistrale in Giurisprudenza, Facoltà di Giurisprudenza, Università di Urbino, 2009, five-year curriculum, score 106/110)

• 2012-present: Coordinator, CNR IASI UOS at Università Cattolica, Policlinico Gemelli.
• 2006-present: Visiting, then Adjunct Professor of Mathematical Statistics, Dept. of Mathematics, Mahidol University, Bangkok, Thailand
• 2003-2005: Visiting Professor of Mathematical Statistics, Dept. of Biostatistics, University of Copenhagen, Denmark
• 2001-2004: Professor of Mathematical Statistics, Università di Urbino, Facoltà di Scienze.
• 2001-present: Dirigente di Ricerca, CNR Istituto di Analisi dei Sistemi ed Informatica "A. Ruberti", Rome.
• 1997-present: Coordinator, BioMathematics Lab, CNR IASI, Rome.
• 1995-2007: Professor of Statistics, School of Internal Medicine, Catholic University, Rome.
• 1990-2001: Ricercatore, CNR Centro di Studio per la Fisiopatologia dello Shock, Rome.
• 1988-1989: Resident in General Surgery, Union Memorial Hospital, Baltimore, MD.
• 1987-1988: Deputy Director, Mathematical Research, Maryland Institute for Emergency Medical Services Systems, Baltimore, MD.
• 1986-1987: Research Fellow, Mathematical Research, Maryland Institute for Emergency Medical Services Systems, Baltimore, MD.

• Parameter estimation for ordinary, delay and stochastic differential models
• Modelling energy metabolism
• Contractual protection of Intellectual Property Rights

• Bilingual Italian-English
• Good spoken and written French
• Good spoken and written German
• Programs fluently in C++, R and Matlab

• Member, ESMTB European Society for Mathematical and Theoretical Biology
• Member, EASD European Association for the Study of Diabetes

• Editor, Mathematical Physiology (in EOLSS, the UNESCO Encyclopedia of Life Support System)
• Associate Editor, International Journal of Mathematics and Mathematical Sciences.
• Associate Editor (Statistics), Intensive Care Medicine 06/2008 - 12/2008
• Past Editor, European Communications in Mathematical and Theoretical Biology
• Referee for several peer-review journals, among which Clinical Chemistry, Diabetologia, American Journal of Physiology, Discrete and Continuous Dynamical Systems, Bulletin of Mathematical Biology, PLOS ONE etc..

• Faculty of Computer Science, State University at Milan
• Faculty of Statistics, State University at Rome 1
• Faculty of Medicine, Catholic University, Rome
• Faculty of Engineering, State University at Rome 1
• PhD Program, Operations Research, State University at Rome 1
• PhD Program, Methodological Statistics, State University at Rome 1
• PhD Program, Mathematical Statistics, Copenhagen University, Denmark
• PhD Program, Mathematics, Mahidol University, Bangkok Thailand

• Papers considered:157 (include Proceedings, Abstracts, Posters and other material not reported in the References list below)
• Citations: 2486 over 26 years, Cites/year: 95.62, Cites/paper: 15.83, Authors/paper: 4.09
• h-index:26, g-index:47, hc-index:16, hI-index:5.68, hI-norm:13, AWCR:299.93, AW-index:17.32, AWCRpA:75.05, e-index:34.70, hm-index:11.73

• Italian Work Ministry 1990-1992, responsible statistician: "Determinants of the mortality from trauma" (multi-center, principal investigator Daniele Gui).
• Telethon 1998-1999, responsible modeller-statistician: "Botulinum toxin in hypertrophic pyloric stenosis (single-center, principal investigator Daniele Gui)
• CNR, National Research Council, 1998-2000, within the strategic project "Mathematical Methods and Models in the Biological Sciences" (principal investigator Mimmo Iannelli): coordinator of subproject "Delay Differential Equations for Endocrine Modelling"
• European Commission 1999, principal investigator : "Summer School on Mathematics in Cell Physiology and Proliferation, Termoli 1999".
• European Commission 2000, principal investigator : "BIOMATHMFRANCA2000 Biomathematics Euro Summer School on 'Spatial Structures in Biology and Ecology: Models and Methods', Martina Franca September 2000".
• Italian Health Ministry 2000-2002, responsible modeller-statistician: "Homocysteine kinetics and health risk" (multi-center, principal investigator Letizia Petroni).
• MURST (Italian Ministry for University and Scientific Research) 2000-2001 "Botulinum toxin action pathways in the central nervous system" (principal investigator Giovanni Zaninotto): responsible statistician for the subunit "Human studies" (Daniele Gui).
• MURST (Italian Ministry for University and Scientific Research) 1999-2001, responsible modeller-statistician: "Integrated strategies for the reduction of mortality in ICU-admitted multiple trauma patients" (multi-center, principal investigator Marco Castagneto).
• European Commission 2002, head of Operating Unit CNR IASI for project "IST-2001-37403 HEARTS Health Early Alarm Recognition and Telemonitoring System", FP5 Information Society Technologies (IST).
• Eli Lilly and Co., 2005 -2007: Research Grant on the modeling of the development of Type 2 Diabetes Mellitus (Principal Investigator)
• European Commission 2006, BioMathTech 07-10: Mathematical Modeling of Physiologial Systems with Biomedical Applications (FP6 Marie Curie Series of Events): Coordinator of the 2009 School on Parameter Estimation for Dynamical Systems.
• European Commission 2008, Scientific Coordinator and Head of CNR IASI Operating Unit for project "FP7-SEC-2007-1-217855 SICMA Simulation of Crisis Management Activities", FP7 Security: Intelligent Decision Support.
• European Commission 2013, Task leader and Head of CNR Operating Unit for project "FP7-SEC-2013 IMPRESS Improving Preparedness and Response of hEalth Services in major criseS" (Health Emergency Management decision support system), contribution to Operating Unit 408 K€ (3.4 M€ total), ongoing.
• European Commission 2013 responsible for modeling and statistical assessment of the results, "FP7-SEC-2013 EDEN End-user Driven dEmo for cbrNe", contribution to Operating Unit 289 K€ (24.8 M€ total), ongoing.
• European Commission 2013 responsible for overall modeling and statistical assessment of the results, "FP7-SEC-2013 PULSE Platform for European Medical Support during major emergencies", contribution to Operating Unit 745 K€ (2.8 M€ total), ongoing.

Since the early years of Medical School, Dr. De Gaetano developed what would become a lifetime commitment to mathematical and statistical methods in biomedical research. He studied and taught biostatistics while in medical school, and was then enrolled in the Master program in Applied Mathematics at UMBC in Baltimore concurrently with his duties as a post-graduate Resident in General Surgery. After his medical degree and Surgery board, he obtained M.Sc. and Ph.D. degrees in Applied Mathematics, focusing on the mathematical statistics of parameter estimation for highly nonlinear and for stochastic dynamical models. He has taught post-graduate and doctoral courses in mathematical statistics and its applications to biomedicine for many years at universities in Rome, Urbino, Copenhagen and Bangkok.

As a result of years of application of computational methods to medicine, he founded in 1997 what is now the Bio-Mathematics Laboratory (BioMatLab) at CNR Istituto di Analisi dei Sistemi ed Informatica "A. Ruberti" (IASI). Through BioMatLab, he persistently engaged in the support of young researchers, suggesting scientific themes and providing funding, thus attracting, over the years, a succession of some thirty doctoral and post-doctoral fellows, Italian and foreign. He has also actively participated in European biomathematics conferences, organizing four EU-funded BioMathematics summer schools as well as contributing to the organization of many different meetings. He has collaborated with the "Direzione Generale per l'Internazionalizzazione della Ricerca" of the Italian Ministry of University and Research, helping to improve Italian participation in European-funded programs. He has actively participated in a number of European projects, coordinating the Operating Units concerned with methodological support and results analysis.

He enrolled in Law School at the University of Urbino in 2002 (where he was teaching Mathematical Statistics at the time), completing the full Laurea Magistrale curriculum in 2009, with a dissertation in Civil Procedure, on quantitative modeling of the impact of the newly introduced Class Action regulations. He has completed his post-graduation Legal Practice with the Studio Legale Pottino in Rome. His legal interests focus on the protection of Intellectual Property Rights, with comparative law aspects. He has typically been entrusted with the drafting of the Intellectual Property sections of the Proposals on behalf of the Consortia with which IASI BioMatLab has competed for EC grants.

Major scientific contributions so far concern diagnostics for flawed estimation in case of high model nonlinearity (as well as numerical schemes to obtain reliable parameter estimates), innovative stochastic differential models in physiology, and the formulation of new models for the glucose/insulin system (as well as the demonstration of their appropriate physiological behavior and statistical robustness). Through collaboration with Medical Doctors and Physiologists on one side, with Engineers, Mathematicians and Statisticians on the other side, different research topics have been investigated, with publications on energy metabolism, pulmonary circulation, respiratory pathophysiology particularly in intensive care, pharmacoeconomy of the control of psychoses, kinetics of bioactive molecules such as hormones and drugs, inhaled drug pharmacokinetics modeling in chronic obstructive pulmonary disease and asthma, immunology of transplant rejection, effects of sublethal exposure to magnetic fields. The reasons for this width of applications lie in the combination of a solid physiological background, of the general applicability of statistical and mathematical analysis for biomedical problems, and of the patient fostering of a team approach to research problems, integrating contributions from people with diverse expertise. Such work has been conducted in close collaborations with several national and foreign research groups, among which Copenhagen, Graz, NCSU Raleigh and Mahidol Bangkok Departments of Mathematics; Paris V Department of Biostatistics; Roskilde Department of BioEngineering; Athens and Harvard Medical Schools.

Current topics of research are: more advanced models for glucose metabolism and long-term diabetes development, efficient algorithms for (population) parameter estimation, the application of modeling for preparedness against health crises (in particular regarding the physiological assessment of a large number of trauma victims), the geostatistical evaluation of pollution and respiratory epidemiological data in Palermo, the development of diagnostic procedures for Cerebral Auto-Regulation dysfunction, the extension of estimation techniques to Individual Based Models and the modeling of violence outbreaks as a support to security decision-makers.

1. Pizzi, R.; De Gaetano, A.; Guadalupi, P.; Chiara, O. On- and Off-Line Surveillance of the Critically Ill Patient. J. Clin. Comput. 1988, 17, 67-72.
2. Laghi, F.; Siegel, J. H.; Rivkind, A. I.; Chiarla, C.; De Gaetano, A.; Blevins, S.; Stoklosa, J. C.; Borg, U. R.; Belzberg, H. Respiratory Index/Pulmonary Shunt Relationship: Quantification of Severity and Prognosis in the Post-Traumatic Adult Respiratory Distress Syndrome. Crit Care Med. 1989, 17, 1121-1128.
3. Coleman, W. P.; Siegel, J. H.; Giovannini, I.; De Gaetano, A.; Goodarzi, S.; Tacchino, R. M.; Sganga, G. Probability and the Patient State Space. Int. J. Clin. Monit. Comput. 1990, 7, 201-215.
4. Coleman, W. P.; Sanford, D. P.; De Gaetano, A.; Geisler, F. H. Functional Models of Neurobiological Processes. J. Math. Comput. Modelling 1990, 14, 317-321.
5. Rivkind, A. I.; Siegel, J. H.; Littleton, M.; De Gaetano, A.; Mamantov, T.; Laghi, F.; Stoklosa, J. C. Neutrophil Oxidative Burst Activation and the Pattern of Respiratory Physiologic Abnormalities in the Fulminant Post-Traumatic Adult Respiratory Distress Syndrome. Circ. Shock 1991, 33, 48-62.
6. Coleman, W. P.; Sanford, D. P.; De Gaetano, A. Sintassi e Semantica Del Linguaggio Descrittivo Dell'Informazione Medica (Syntax and Semantics of the Language Describing Medical Information). Medicina e Informatica 1992, 3, 169-171.
7. Greco, A. V.; Mingrone, G.; Raguso, C.; Tataranni, A.; Finotti, E.; Tacchino, R. M.; Capristo, E.; De Gaetano, A.; Castagneto, M. Metabolic Effects and Disposition of Sebacate, an Alternate Dicarboxylic Fuel Substrate. Ann. Nutr. Metab 1992, 36, 1-11.
8. Tataranni, P. A.; Mingrone, G.; De Gaetano, A.; Raguso, C.; Greco, A. V. Tracer Study of Metabolism and Tissue Distribution of Sebacic Acid in Rats. Ann. Nutr. Metab 1992, 36, 296-303.
9. Coleman, W. P.; Siegel, J. H.; Giovannini, I.; Sanford, D. P.; De Gaetano, A. Computational Logic: a Method for Formal Analysis of the ICU Knowledge Base. Int. J. Clin. Monit. Comput. 1993, 10, 67-79.
10. De Gaetano, A.; Coleman, W. P.; Pizzi, R.; Tomasella, E.; Castagneto, M.; Greco, A. V. Hydra: a C-Language Environment for Real-Time DOS Multitasking at the Bedside. Int. J. Clin. Monit. Comput. 1993, 10, 147-154.
11. Greco, A. V.; Mingrone, G.; Tataranni, P. A.; Raguso, C.; De Gaetano, A.; Tacchino, R. M.; Lavielle, R.; Ghirlanda, G. Turnover and Oxidation Rates of Plasma-Free Fatty Acids in Obese Patients Treated With Dexfenfluramine. Ann. Nutr. Metab 1993, 37, 237-244.
12. Mingrone, G.; De Gaetano, A.; Greco, A. V.; Capristo, E.; Raguso, C.; Tataranni, P. A.; Castagneto, M. A Rapid GLC Method for the Direct Analysis of Plasma Medium Chain Fatty Acids. Clin. Chim. Acta 1993, 214, 21-30.
13. Mingrone, G.; Greco, A. V.; Castagneto, M.; De Gaetano, A.; Tataranni, P. A.; Raguso, C. Kinetics and Thermogenesis of Medium-Chain Monocarboxylic and Dicarboxylic Acids in Man: Sebacate and Medium-Chain Triglycerides. JPEN J. Parenter. Enteral Nutr. 1993, 17, 257-264.
14. Castagneto, M.; De Gaetano, A.; Mingrone, G.; Tacchino, R.; Nanni, G.; Capristo, E.; Benedetti, G.; Tataranni, P. A.; Greco, A. V. Normalization of Insulin Sensitivity in the Obese Patient After Stable Weight Reduction With Biliopancreatic Diversion. Obes. Surg. 1994, 4, 161-168.
15. De Gaetano, A.; Castagneto, M.; Mingrone, G.; Coleman, W. P.; Sganga, G.; Tataranni, P. A.; Gangeri, G.; Greco, A. V. PC-Based Differential Model Fitting As a Support for Clinical Research. Int. J. Clin. Monit. Comput. 1994, 11, 35-41.
16. De Gaetano, A.; Castagneto, M.; Mingrone, G.; Gangeri, G.; Sganga, G.; Tataranni, P. A.; Raguso, C.; Greco, A. V. Kinetics of Medium-Chain Triglycerides and Free Fatty Acids in Healthy Volunteers and Surgically Stressed Patients. JPEN J. Parenter. Enteral Nutr. 1994, 18, 134-140.
17. Mingrone, G.; Greco, A. V.; De Gaetano, A.; Tataranni, A.; Raguso, C.; Castagneto, M. Pharmacokinetic Profile of Dodecanedioic Acid, a Proposed Alternative Fuel Substrate. JPEN J. Parenter. Enteral Nutr. 1994, 18, 225-230.
18. Raguso, C. A.; Mingrone, G.; Greco, A. V.; Tataranni, P. A.; De Gaetano, A.; Castagneto, M. Dicarboxylic Acids and Glucose Utilization in Humans: Effect of Sebacate. JPEN J. Parenter. Enteral Nutr. 1994, 18, 9-13.
19. Scambia, G.; Benedetti, P. P.; Foti, E.; Amoroso, M.; Salerno, G.; Ferrandina, G.; Battaglia, F.; Greggi, S.; De Gaetano, A.; Puglia, G. Squamous Cell Carcinoma Antigen: Prognostic Significance and Role in the Monitoring of Neoadjuvant Chemotherapy Response in Cervical Cancer. J. Clin. Oncol. 1994, 12, 2309-2316.
20. Tataranni, P. A.; Mingrone, G.; Greco, A. V.; Caradonna, P.; Capristo, E.; Raguso, C. A.; De Gaetano, A.; Tacchino, R. M.; Castagneto, M. Glucose-Induced Thermogenesis in Postobese Women Who Have Undergone Biliopancreatic Diversion. Am. J. Clin. Nutr. 1994, 60, 320-326.
21. Greco, A. V.; Tataranni, P. A.; Mingrone, G.; De Gaetano, A.; Manto, A.; Cotroneo, P.; Ghirlanda, G. Daily Energy Metabolism in Patients With Type 1 Diabetes Mellitus. J. Am. Coll. Nutr. 1995, 14, 286-291.
22. Greco, A. V.; Mingrone, G.; Capristo, E.; De Gaetano, A.; Ghirlanda, G.; Castagneto, M. Effects of Dexfenfluramine on Free Fatty Acid Turnover and Oxidation in Obese Patients With Type 2 Diabetes Mellitus. Metabolism 1995, 44, 57-61.
23. Mingrone, G.; De Gaetano, A.; Greco, A. V.; Capristo, E.; Castagneto, M.; Gasbarrini, G. Medium-Chain Triglycerides for Parenteral Nutrition: Kinetic Profile in Humans. Nutrition 1995, 11, 418-422.
24. De Gaetano, A.; Mingrone, G.; Castageneto, M. NONMEM Improves Group Parameter Estimation for the Minimal Model of Glucose Kinetics. Am. J. Physiol 1996, 271, E932-E937.
25. Gui, D.; Spada, P. L.; De Gaetano, A.; Pacelli, F. Hypocholesterolemia and Risk of Death in the Critically Ill Surgical Patient. Intensive Care Med. 1996, 22, 790-794.
26. Mingrone, G.; De Gaetano, A.; Greco, A. V.; Benedetti, G.; Capristo, E.; Castagneto, M.; Gasbarrini, G. Plasma Clearance and Oxidation of Dodecanedioic Acid in Humans. JPEN J. Parenter. Enteral Nutr. 1996, 20, 38-42.
27. Tataranni, P. A.; Mingrone, G.; Raguso, C. A.; De Gaetano, A.; Tacchino, R. M.; Castagneto, M.; Greco, A. V. Twenty-Four-Hour Energy and Nutrient Balance in Weight Stable Postobese Patients After Biliopancreatic Diversion. Nutrition 1996, 12, 239-244.
28. Bertuzzi, A.; Mingrone, G.; De Gaetano, A.; Gandolfi, A.; Greco, A. V.; Salinari, S. Kinetics of Dodecanedioic Acid and Effect of Its Administration on Glucose Kinetics in Rats. Br. J. Nutr. 1997, 78, 143-153.
29. Greco, A. V.; Mingrone, G.; De Gaetano, A.; Amigo, L.; Puglielli, L.; Castagneto, M.; Nervi, F. Uptake of Dodecanedioic Acid by Isolated Rat Liver. Clin. Chim. Acta 1997, 258, 209-218.
30. Mingrone, G.; De Gaetano, A.; Greco, A. V.; Capristo, E.; Benedetti, G.; Castagneto, M.; Gasbarrini, G. Reversibility of Insulin Resistance in Obese Diabetic Patients: Role of Plasma Lipids. Diabetologia 1997, 40, 599-605.
31. Mingrone, G.; De Gaetano, A.; Greco, A. V.; Capristo, E.; Benedetti, G.; Castagneto, M.; Gasbarrini, G. Dodecanedioic Acid Infusion Induces a Sparing Effect on Whole-Body Glucose Uptake, Mainly in Non-Insulin-Dependent Diabetes Mellitus. Br. J. Nutr. 1997, 78, 723-735.
32. Castagneto, M.; De Gaetano, A.; Mingrone, G.; Capristo, E.; Benedetti, G.; Tacchino, R. M.; Greco, A. V.; Gasbarrini, G. A Surgical Option for Familial Chylomicronemia Associated With Insulin- Resistant Diabetes Mellitus. Obes. Surg. 1998, 8, 191-198.
33. Greco, A. V.; Mingrone, G.; Capristo, E.; Benedetti, G.; De Gaetano, A.; Gasbarrini, G. The Metabolic Effect of Dodecanedioic Acid Infusion in Non-Insulin- Dependent Diabetic Patients. Nutrition 1998, 14, 351-357.
34. Mingrone, G.; Benedetti, G.; Capristo, E.; De Gaetano, A.; Greco, A. V.; Tataranni, P. A.; Gasbarrini, G. Twenty-Four-Hour Energy Balance in Crohn Disease Patients: Metabolic Implications of Steroid Treatment. Am. J. Clin. Nutr. 1998, 67, 118-123.
35. Andreotti, F.; Sciahbasi, A.; De Gaetano, A.; Benedetti, G.; Mingrone, G.; Greco, A. V.; Maseri, A. Comparison of Insulin Response to Intravenous Glucose in Healed Myocardial Infarction, in "Cooled-Off" Unstable and Stable Angina Pectoris, and in Healthy Subjects. Am. J. Cardiol. 1999, 84, 870-875.
36. Capristo, E.; De Gaetano, A.; Mingrone, G.; Addolorato, G.; Greco, A. V.; Castagneto, M.; Gasbarrini, G. Multivariate Identification of Metabolic Features in Inflammatory Bowel Disease. Metabolism 1999, 48, 952-956.
37. Capristo, E.; Mingrone, G.; De Gaetano, A.; Addolorato, G.; Greco, A. V.; Gasbarrini, G. A New HPLC Method for the Direct Analysis of Triglycerides of Dicarboxylic Acids in Biological Samples. Clin. Chim. Acta 1999, 289, 11-21.
38. De Gaetano, A.; Mingrone, G.; Castagneto, M.; Benedetti, G.; Greco, A. V.; Gasbarrini, G. Kinetics of Dodecanedioic Acid Triglyceride in Rats. Am. J. Physiol 1999, 276, E497-E502.
39. De Gaetano, A.; Mingrone, G.; Castagneto, M.; Calvani, M. Carnitine Increases Glucose Disposal in Humans. J. Am. Coll. Nutr. 1999, 18, 289-295.
40. De Gaetano, A.; Arino, O. Probabilistic Determination of Stability for a Delay-Differential Model of the Glucose-Insulin Dynamical System. J. Biol. Systems 1999, 7(2), 131-144.
41. Mingrone, G.; De Gaetano, A.; Greco, A. V.; Capristo, E.; Benedetti, G.; Castagneto, M.; Gasbarrini, G. Comparison Between Dodecanedioic Acid and Long-Chain Triglycerides As an Energy Source in Liquid Formula Diets. JPEN J. Parenter. Enteral Nutr. 1999, 23, 80-84.
42. Mingrone, G.; Greco, A. V.; Capristo, E.; Benedetti, G.; Giancaterini, A.; De Gaetano, A.; Gasbarrini, G. L-Carnitine Improves Glucose Disposal in Type 2 Diabetic Patients. J. Am. Coll. Nutr. 1999, 18, 77-82.
43. Mingrone, G.; De Gaetano, A.; Pugeat, M.; Capristo, E.; Greco, A. V.; Gasbarrini, G. The Steroid Resistance of Crohn's Disease. J. Investig. Med. 1999, 47, 319-325.
44. Mingrone, G.; Capristo, E.; Greco, A. V.; Benedetti, G.; De Gaetano, A.; Tataranni, P. A.; Gasbarrini, G. Elevated Diet-Induced Thermogenesis and Lipid Oxidation Rate in Crohn Disease. Am. J. Clin. Nutr. 1999, 69, 325-330.
45. Bartolozzi, F.; De Gaetano, A.; Di Lena, E.; Marino, S.; Nieddu, L.; Patrizi, G. Operational Research Techniques in Medical Treatment and Diagnosis. A Review. European Journal of Operations Research, EJOR 2000, 121/3, 435-466.
46. Capristo, E.; Addolorato, G.; Mingrone, G.; De Gaetano, A.; Greco, A. V.; Tataranni, P. A.; Gasbarrini, G. Changes in Body Composition, Substrate Oxidation, and Resting Metabolic Rate in Adult Celiac Disease Patients After a 1-y Gluten-Free Diet Treatment. Am. J. Clin. Nutr. 2000, 72, 76-81.
47. De Gaetano, A.; Arino, O. A Statistical Approach to the Determination of Stability for Dynamical Systems Modelling Physiological Processes. J. Math. Comput. Modelling 2000, 31, 41-51.
48. De Gaetano, A.; Arino, O. Mathematical Modelling of the Intravenous Glucose Tolerance Test. J. Math. Biol. 2000, 40, 136-168.
49. Giancaterini, A.; De Gaetano, A.; Mingrone, G.; Gniuli, D.; Liverani, E.; Capristo, E.; Greco, A. V. Acetyl-L-Carnitine Infusion Increases Glucose Disposal in Type 2 Diabetic Patients. Metabolism 2000, 49, 704-708.
50. Gui, D.; De Gaetano, A.; Spada, P. L.; Viggiano, A.; Cassetta, E.; Albanese, A. Botulinum Toxin Injected in the Gastric Wall Reduces Body Weight and Food Intake in Rats. Aliment. Pharmacol. Ther. 2000, 14, 829-834.
51. Manco, M.; Mingrone, G.; Greco, A. V.; Capristo, E.; Gniuli, D.; De Gaetano, A.; Gasbarrini, G. Insulin Resistance Directly Correlates With Increased Saturated Fatty Acids in Skeletal Muscle Triglycerides. Metabolism 2000, 49, 220-224.
52. Purro, A.; Appendini, L.; De Gaetano, A.; Gudjonsdottir, M.; Donner, C. F.; Rossi, A. Physiologic Determinants of Ventilator Dependence in Long-Term Mechanically Ventilated Patients. Am. J. Respir. Crit Care Med. 2000, 161, 1115-1123.
53. Calvani, M.; Iddio, D.; De Gaetano, A.; Mariotti, P.; Mosconi, L.; Pomponi, M. G.; Tabolacci, E.; Torrioli, M. G.; Vernacotola, S.; Neri, G. [L Acetylcarnitine Treatment on Fragile X Patients Hyperactive Behaviour]. Rev. Neurol. 2001, 33 Suppl 1, S65-S70.
54. Giancaterini, A.; Mingrone, G.; De Gaetano, A.; Capristo, E.; Calvani, M.; Caso, V.; Greco, A. V.; Gasbarrini, G. Effects of Propyonil-l-Carnitine Topical Irrigation in Distal Ulcerative Colitis: a Preliminary Report. Am. J. Gastroenterol. 2001, 96, 2275-2276.
55. Mingrone, G.; Marino, S.; De Gaetano, A.; Capristo, E.; Heymsfield, S. B.; Gasbarrini, G.; Greco, A. V. Different Limit to the Body's Ability of Increasing Fat-Free Mass. Metabolism 2001, 50, 1004-1007.
56. Graziano, F.; Bisonni, R.; Catalano, V.; Silva, R.; Rovidati, S.; Mencarini, E.; Ferraro, B.; Canestrari, F.; Baldelli, A. M.; De Gaetano, A.; Giordani, P.; Testa, E.; Lai, V. Potential Role of Levocarnitine Supplementation for the Treatment of Chemotherapy-Induced Fatigue in Non-Anaemic Cancer Patients. Br. J. Cancer 2002, 86, 1854-1857.
57. Gui, D.; Runfola, M.; Rossi, S.; Panunzi, S.; De Gaetano, A. Academic Recruitment in Spain and Italy. Science 2002, 297, 770-771.
58. Marino, S.; De Gaetano, A.; Giancaterini, A.; Giordano, D.; Manco, M.; Greco, A. V.; Mingrone, G. Computing DIT From Energy Expenditure Measures in a Respiratory Chamber: a Direct Modeling Method. Comput. Biol. Med. 2002, 32, 297-309.
59. Gasbarrini, G.; Mingrone, G.; Giancaterini, A.; De Gaetano, A.; Scarfone, A.; Capristo, E.; Calvani, M.; Caso, V.; Greco, A. V. Effects of Propionyl-L-Carnitine Topical Irrigation in Distal Ulcerative Colitis: a Preliminary Report. Hepatogastroenterology 2003, 50, 1385-1389.
60. Muretto, P.; Graziano, F.; Staccioli, M. P.; Barbanti, I.; Bartolucci, A.; Paolini, G.; Giordano, D.; Testa, E.; De Gaetano, A. An Endogastric Capsule for Measuring Tumor Markers in Gastric Juice: an Evaluation of the Safety and Efficacy of a New Diagnostic Tool. Ann. Oncol. 2003, 14, 105-109.
61. Ruzzo, A.; Graziano, F.; Costagliola, A.; Arduini, F.; Testa, E.; Bearzi, I.; Cortese, G.; De Gaetano, A.; Andreoni, F.; Lai, V.; Magnani, M. The G/A Nucleotide Change at CDNA Position 2494 in the E-Cadherin Gene (CDH1): Analysis in Italian Patients. Tumour. Biol. 2003, 24, 147-150.
62. Severini, M.; Dattilo, A. M.; De Gaetano, A. Sublethal Effect of a Weak Intermittent Magnetic Field on the Development of Xenopus Laevis (Daudin) Tadpoles. Int. J. Biometeorol. 2003, 48, 91-97.
63. De Gaetano, A.; Cortese, G.; Pedersen, M. G.; Panunzi, S.; Picchini, U.; Morelli, A. Modeling Serum Creatinine in Septic ICU Patients. Cardiovascular Engineering 2004, 4, 173-180.
64. De Gaetano, A.; Cremona, G. Direct Estimation of General Pulmonary Vascular Models From Occlusion Experiments. Cardiovascular Engineering 2004, 4, 103-114.
65. Morelli, A.; Rocco, M.; Conti, G.; Orecchioni, A.; De Gaetano, A.; Cortese, G.; Coluzzi, F.; Vernaglione, E.; Pelaia, P.; Pietropaoli, P. Effects of Terlipressin on Systemic and Regional Haemodynamics in Catecholamine-Treated Hyperkinetic Septic Shock. Intensive Care Med. 2004, 30, 597-604.
66. Morelli, A.; Rocco, M.; Conti, G.; Orecchioni, A.; De Gaetano, A.; Coluzzi, F.; Vernaglione, E.; Pelaia, P.; Pietropaoli, P. Effects of Short-Term Fenoldopam Infusion on Gastric Mucosal Blood Flow in Septic Shock. Anesthesiology 2004, 101, 576-582.
67. Mukhopadhyay, A.; De Gaetano, A.; Arino, O. Modelling the Intra-Venous Glucose Tolerance Test: a Global Study for a Single-Distributed-Delay Model. Discr. Cont. Dyn. Syst. B 2004.
68. Ciampelli, M.; Leoni, F.; Cucinelli, F.; Mancuso, S.; Panunzi, S.; De Gaetano, A.; Lanzone, A. Assessment of Insulin Sensitivity From Measurements in the Fasting State and During an Oral Glucose Tolerance Test in Polycystic Ovary Syndrome and Menopausal Patients. J. Clin. Endocrinol. Metab 2005, 90, 1398-1406.
69. De Gaetano, A.; Di Martino, D.; Germani, A.; Manes, C. Mathematical Models and State Observation of the Glucose-Insulin Homeostasis. System Modeling and Optimization 166, 281-294. 2005. IFIP International Federation for Information Processing.
70. Ditlevsen, S.; De Gaetano, A. Stochastic Vs. Deterministic Uptake of Dodecanedioic Acid by Isolated Rat Livers. Bull. Math. Biol. 2005, 67, 547-561.
71. Ditlevsen, S.; De Gaetano, A. Mixed Effects in Stochastic Differential Equations Models. REVSTAT 2005, 3, 137-153.
72. Morelli, A.; Ricci, Z.; Bellomo, R.; Ronco, C.; Rocco, M.; Conti, G.; De Gaetano, A.; Picchini, U.; Orecchioni, A.; Portieri, M.; Coluzzi, F.; Porzi, P.; Serio, P.; Bruno, A.; Pietropaoli, P. Prophylactic Fenoldopam for Renal Protection in Sepsis: a Randomized, Double-Blind, Placebo-Controlled Pilot Trial. Crit Care Med. 2005, 33, 2451-2456.
73. Morelli, A.; Tritapepe, L.; Rocco, M.; Conti, G.; Orecchioni, A.; De Gaetano, A.; Picchini, U.; Pelaia, P.; Reale, C.; Pietropaoli, P. Terlipressin Versus Norepinephrine to Counteract Anesthesia-Induced Hypotension in Patients Treated With Renin-Angiotensin System Inhibitors: Effects on Systemic and Regional Hemodynamics. Anesthesiology 2005, 102, 12-19.
74. Panunzi, S.; De Gaetano, A.; Mingrone, G. Approximate Linear Confidence and Curvature of a Kinetic Model of Dodecanedioic Acid in Humans. Am. J. Physiol Endocrinol. Metab 2005, 289, E915-E922.
75. Picchini, U.; De Gaetano, A.; Panunzi, S.; Ditlevsen, S.; Mingrone, G. A Mathematical Model of the Euglycemic Hyperinsulinemic Clamp. Theor. Biol. Med. Model. 2005, 2, 44.
76. Clausen, W. H.; De Gaetano, A.; Volund, A. Within-Patient Variation of the Pharmacokinetics of Subcutaneously Injected Biphasic Insulin Aspart As Assessed by Compartmental Modelling. Diabetologia 2006, 49, 2030-2038.
77. Morelli, A.; Teboul, J. L.; Maggiore, S. M.; Vieillard-Baron, A.; Rocco, M.; Conti, G.; De Gaetano, A.; Picchini, U.; Orecchioni, A.; Carbone, I.; Tritapepe, L.; Pietropaoli, P.; Westphal, M. Effects of Levosimendan on Right Ventricular Afterload in Patients With Acute Respiratory Distress Syndrome: a Pilot Study. Crit Care Med. 2006, 34, 2287-2293.
78. Palumbo, P.; Ong Clausen, W. H.; Panunzi, S.; De Gaetano, A. Linear Periodic Models of Subcutaneous Insulin Absorption: Mathematical Analysis. HERMIS Journal 2006, 7, 60-79.
79. Pavoni, E.; Pucci, A.; Vaccaro, P.; Monteriu, G.; Ceratti, A. P.; Lugini, A.; Virdis, R. A.; Cortesi, E.; De Gaetano, A.; Panunzi, S.; Felici, F.; Minenkova, O. A Study of the Humoral Immune Response of Breast Cancer Patients to a Panel of Human Tumor Antigens Identified by Phage Display. Cancer Detect. Prev. 2006, 30, 248-256.
80. Picchini, U.; Ditlevsen, S.; De Gaetano, A. Modeling the Euglycemic Hyperinsulinemic Clamp by Stochastic Differential Equations. J. Math. Biol. 2006, 53, 771-796.
81. Rusciani, L.; Proietti, I.; Rusciani, A.; Paradisi, A.; Sbordoni, G.; Alfano, C.; Panunzi, S.; De Gaetano, A.; Lippa, S. Low Plasma Coenzyme Q10 Levels As an Independent Prognostic Factor for Melanoma Progression. J. Am. Acad. Dermatol. 2006, 54, 234-241.
82. Palumbo, P.; Panunzi, S.; De Gaetano, A. Qualitative Behavior of a Family of Delay-Differential Models of the Glucose-Insulin System. Discrete and Continuous Dynamical Systems - Series B 2007, 7, 399-424.
83. Panunzi, S.; Palumbo, P.; De Gaetano, A. A Discrete Single Delay Model for the Intra-Venous Glucose Tolerance Test. Theor. Biol. Med. Model. 2007, 4, 35.
84. Rusciani, L.; Proietti, I.; Paradisi, A.; Rusciani, A.; Guerriero, G.; Mammone, A.; De Gaetano, A.; Lippa, S. Recombinant Interferon Alpha-2b and Coenzyme Q10 As a Postsurgical Adjuvant Therapy for Melanoma: a 3-Year Trial With Recombinant Interferon-Alpha and 5-Year Follow-Up. Melanoma Res. 2007, 17, 177-183.
85. De Gaetano, A.; Hardy, T.; Beck, B.; Abu-Raddad, E.; Palumbo, P.; Bue-Valleskey, J.; Porksen, N. Mathematical Models of Diabetes Progression. Am. J. Physiol Endocrinol. Metab 2008, 295, E1462-E1479.
86. Morganti, A. G.; Deodato, F.; Zizzari, S.; Cilla, S.; Digesu', C.; Macchia, G.; Panunzi, S.; De Gaetano, A.; Piermattei, A.; Cellini, N.; Valentini, V. Complexity Index (COMIX) and Not Type of Treatment Predicts Undetected Errors in Radiotherapy Planning and Delivery. Radiother. Oncol. 2008, 89, 320-329.
87. Palumbo, P.; Picchini, U.; Beck, B.; van, G. J.; Delbar, N.; De Gaetano, A. A General Approach to the Apparent Permeability Index. J. Pharmacokinet. Pharmacodyn. 2008, 35, 235-248.
88. Picchini, U.; Ditlevsen, S.; De Gaetano, A. Maximum Likelihood Estimation of a Time-Inhomogeneous Stochastic Differential Model of Glucose Dynamics. Math. Med. Biol. 2008, 25, 141-155.
89. Picchini, U.; Ditlevsen, S.; De Gaetano, A.; Lansky, P. Parameters of the Diffusion Leaky Integrate-and-Fire Neuronal Model for a Slowly Fluctuating Signal. Neural Comput. 2008, 20, 2696-2714.
90. Morganti, A. G.; Digesu, C.; Panunzi, S.; De Gaetano, A.; Macchia, G.; Deodato, F.; Cece, M. G.; Cirocco, M.; Di, C. A.; Iacoviello, L.; Valentini, V.; Cellini, N.; de Gaetano, G. Radioprotective Effect of Moderate Wine Consumption in Patients With Breast Carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2009, 74, 1501-1505.
91. Morganti, A. G.; Cilla, S.; Valentini, V.; Digesu', C.; Macchia, G.; Deodato, F.; Ferrandina, G.; Cece, M. G.; Cirocco, M.; Garganese, G.; Di, L. L.; Traficante, D.; Scarabeo, F.; Panunzi, S.; De Gaetano, A.; Sallustio, G.; Cellini, N.; Sofo, L.; Piermattei, A.; Scambia, G. Phase I-II Studies on Accelerated IMRT in Breast Carcinoma: Technical Comparison and Acute Toxicity in 332 Patients. Radiother. Oncol. 2009, 90, 86-92.
92. Palumbo, P.; De Gaetano, A. An Islet Population Model of the Endocrine Pancreas. J. Math. Biol. 2010, 61, 171-205.
93. Panunzi, S.; De Gaetano, A.; Mingrone, G. Advantages of the Single Delay Model for the Assessment of Insulin Sensitivity From the Intravenous Glucose Tolerance Test. Theor. Biol. Med. Model. 2010, 7, 9.
94. Picchini, U.; Ditlevsen, S.; De Gaetano, A. Stochastic Differential Mixed-Effects Models. Scand. J. Stat. 2010, 37, 67-90.
95. Digesu, C.; Cilla, S.; De Gaetano, A.; Massaccesi, M.; Macchia, G.; Ippolito, E.; Deodato, F.; Panunzi, S.; Iapalucci, C.; Mattiucci, G. C.; D'Angelo, E.; Padula, G. D.; Valentini, V.; Cellini, N.; Piermattei, A.; Morganti, A. G. Postoperative Intensity Modulated Radiation Therapy in High Risk Prostate Cancer: a Dosimetric Comparison. Med. Dosim. 2011, 36, 231-239.
96. Iaconelli, A.; Panunzi, S.; De Gaetano, A.; Manco, M.; Guidone, C.; Leccesi, L.; Gniuli, D.; Nanni, G.; Castagneto, M.; Ghirlanda, G.; Mingrone, G. Effects of Bilio-Pancreatic Diversion on Diabetic Complications: A 10-Year Follow-Up. Diabetes Care 2011, 34, 561-567.
97. Morganti, A. G.; Cilla, S.; De Gaetano, A.; Panunzi, S.; Digesu, C.; Macchia, G.; Massaccesi, M.; Deodato, F.; Ferrandina, G.; Cellini, N.; Scambia, G.; Piermattei, A.; Valentini, V. Forward Planned Intensity Modulated Radiotherapy (IMRT) for Whole Breast Postoperative Radiotherapy. Is It Useful? When? J. Appl. Clin. Med. Phys. 2011, 12, 3451.
98. Antonelli, M.; De, P. G.; Ranieri, V. M.; Pelaia, P.; Tufano, R.; Piazza, O.; Zangrillo, A.; Ferrario, A.; De Gaetano, A.; Guaglianone, E.; Donelli, G. Comparison of Triple-Lumen Central Venous Catheters Impregnated With Silver Nanoparticles (AgTive((R))) Vs Conventional Catheters in Intensive Care Unit Patients. J. Hosp. Infect. 2012, 82, 101-107.
99. De Gaetano, A.; Matone, A.; Agnes, A. M.; Palumbo, P.; Ria, F.; Magalini, S. Modeling Rejection Immunity. Theor. Biol. Med. Model. 2012, 9-18.
100. Gaz, C.; Cremona, G.; Panunzi, S.; Patterson, B.; De Gaetano, A. A Geometrical Approach to the PKPD Modelling of Inhaled Bronchodilators. J. Pharmacokinet. Pharmacodyn. 2012, 39, 415-428.
101. Hardy, T.; Abu-Raddad, E.; Porksen, N.; De Gaetano, A. Evaluation of a Mathematical Model of Diabetes Progression Against Observations in the Diabetes Prevention Program. Am. J. Physiol Endocrinol. Metab 2012, 303, E200-E212.
102. Li, J.; Wang, M.; De Gaetano, A.; Palumbo, P.; Panunzi, S. The Range of Time Delay and the Global Stability of the Equilibrium for an IVGTT Model. Math. Biosci. 2012, 235, 128-137.
103. Magalini, S.; Pepe, G.; Panunzi, S.; Spada, P. L.; De Gaetano, A.; Gui, D. An Economic Evaluation of Clostridium Difficile Infection Management in an Italian Hospital Environment. Eur. Rev. Med. Pharmacol. Sci. 2012, 16, 2136-2141.
104. Mingrone, G.; Panunzi, S.; De Gaetano, A.; Guidone, C.; Raffaelli, M.; Callari, C.; Lombardi, P. C.; Bellantone, R. Protocol for a Randomised Clinical Study Comparing the Effect of Roux-En-Y Gastric Bypass and Sleeve Gastrectomy on Reactive Hypoglycaemia in Morbidly Obese Subjects. BMJ Open. 2012, 2.
105. Mingrone, G.; Panunzi, S.; De Gaetano, A.; Guidone, C.; Iaconelli, A.; Leccesi, L.; Nanni, G.; Pomp, A.; Castagneto, M.; Ghirlanda, G.; Rubino, F. Bariatric Surgery Versus Conventional Medical Therapy for Type 2 Diabetes. N. Engl. J. Med. 2012, 366, 1577-1585.
106. Palumbo, P.; Pepe, P.; Panunzi, S.; De Gaetano, A. Time-Delay Model-Based Control of the Glucose-Insulin System, by Means of a State Observer. European Journal of Control 2012, 6, 591-606.
107. Toghaw, P.; Matone, A.; Lenbury, Y.; De Gaetano, A. Bariatric Surgery and T2DM Improvement Mechanisms: a Mathematical Model. Theor. Biol. Med. Model. 2012, 9, 16.
108. Iesari, S.; le Roux, C. W.; De Gaetano, A.; Manco, M.; Nanni, G.; Mingrone, G. Twenty-Four Hour Energy Expenditure and Skeletal Muscle Gene Expression Changes After Bariatric Surgery. J Clin. Endocrinol. Metab 2013, 98, E321-E327.
109. Leccesi, L.; Panunzi, S.; De Gaetano, A.; Familiari, P.; Iaconelli, A.; Guidone, C.; Mazzarella, A.; Costamagna, G.; Mingrone, G. Effects of Transoral Gastroplasty on Glucose Homeostasis in Obese Subjects. J Clin. Endocrinol. Metab 2013.
110. Sloan-Lancaster, J.; Abu-Raddad, E.; Polzer, J.; Miller, J. W.; Scherer, J. C.; De Gaetano, A.; Berg, J. K.; Landschulz, W. H. Double-Blind, Randomized Study Evaluating the Glycemic and Anti-Inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1beta Antibody, in Patients With Type 2 Diabetes. Diabetes Care 2013.

1. De Gaetano, A.; Coleman, W. P. Surgical Informatics. In General Surgery: Current Status and Future Trends; Starzl, T. E., Montorsi, W., Eds.; Raven Press: New York, 1990.
2. Tataranni, P. A.; Ghirlanda, G.; Mingrone, G.; Cotroneo, P.; Manto, A.; Raguso, C. A.; De Gaetano, A.; Greco, A. V. Energy Balance in Insulin-Dependent Diabetes Mellitus Patients by Respiration Chamber. In Current Topics in Diabetes Research, Frontiers in Diabetes; Belfiore, F., Bergman, R. N., Molinatti, G. M., Eds.; Karger: Basel, 1993.
3. De Gaetano, A. Perspectives and Challenges of BioMathematics for the First Years of the New Millennium. In Applicable Mathematics; Misra, J. C., Ed.; Narosa: 2000.
4. Mukhopadhyay, A.; De Gaetano, A.; Arino, O.; Mingrone, G.; Castagneto, M. A Single-Distributed-Delay Model of the Intra-Venous Glucose Tolerance Test: a Global Study. In Applicable Mathematics; Misra, J. C., Ed.; Narosa: 2000.
5. De Gaetano, A.; Panunzi, S. Nonlinear Estimation and Confidence Regions: a Biological Case Study. In Mathematical Models for Bioengineering and Probabilistic Systems; Misra, J. C., Ed.; Narosa: New Delhi, 2005.
6. De Gaetano, A.; Panunzi, S.; Beck, B.; Boulanger, B. Statistical Modeling in Pharmaceutical Research and Development. In Computer Applications in Pharmaceutical Research and Development; Ekins, S., Ed.; Wiley: Hoboken NJ, 2006; Chapter 3.